Proper patient counseling of the risks versus benefits of is very important to ensure compliance with therapy. Awareness of the possibility of transient exacerbation of acne is important.
Check that the drug is being taken with fatty food to enhance drug absorption
Actively manage the side-effects. Remember that topical antibiotics and occasionally topical corticosteroids may be required for the skin, lip side-effects
The dose can be lowered temporarily if fatigue, joint pains ,mood changes or if other side-effects are very troubling and might interfere with continuing therapy.
